6 Picks for College Football Week 2

Hail Mary Media
September 05, 2025

Let’s be straight. Week 2 separates people who talk from people who bet with conviction. Six picks. Real numbers behind each. No fluff.

Pitt vs Central Michigan Over 49.5
Pitt hung 61 on Week 1 and moved the ball like a team built to score in chunks. CMU runs a heavy volume offense and their pass defense showed real holes last week. That combo, Pitt’s explosiveness plus CMU’s ability to extend drives, creates enough possessions and busted coverages to push this past 50.
Pick wins because Pitt’s big-play ability and CMU’s pace make scoring inevitable.
Bet: Over 49.5

Iowa vs Iowa State Iowa +3.5
Cy-Hawk is a grind. Iowa’s defense looks like Iowa, steady, slow-the-clock, no nonsense. ISU lit up a weak foe last week, but this is a different animal. Rivalry games are ugly and possession-heavy. Give me the points and the defense that’ll make those points matter.
Pick wins because Iowa’s defense grinds ISU’s efficiency down and 3.5 is coverable in a slog.
Bet: Iowa +3.5

Oregon vs Oklahoma State Oregon -28
Oregon blew out Michigan State and looked like a top offense. OSU’s dealing with injuries and turnover. Autzen gets loud, Oregon plays fast, and the Cowboys don’t have the pieces to hang when the Ducks start pushing tempo. This is a snowball.
Pick wins because Oregon’s depth and pace will turn small advantages into a rout.
Bet: Oregon -28

Kentucky vs Ole Miss Kentucky +8.5
Ole Miss is explosive when clean, but they showed some turnover issues and hiccups early. Kentucky can slow the game, hold the ball, and keep the scoreboard from exploding. Eight and a half points in a game Kentuckians can make ugly is a number you take.
Pick wins because Kentucky controls time of possession and limits Ole Miss’s splash plays.
Bet: Kentucky +8.5

UNLV vs UCLA UNLV ML
UCLA is still sorting things out. UNLV is 2–0, confident at home, and not an easy out. Market money treats this close for a reason. If UCLA’s offense stays sloppy, the Rebels finish this, special teams and cleaner execution win tight spots.
Pick wins because UNLV executes cleaner in high-leverage moments.
Bet: UNLV ML

Oklahoma vs Michigan Oklahoma -5
Michigan’s rookie QB looked decent, but now he’s facing a hostile road crowd and a pass rush that can shorten secondaries’ decision windows. OU has the explosive plays and the home advantage. Rookie timing plus pressure equals mistakes. I’ll take the Sooners.
Pick wins because OU’s pass rush speeds the young QB’s reads and tilts the game toward Oklahoma’s big plays.
Bet: Oklahoma -5

TL;DR No bullshit, just picks

Over 49.5 Pitt vs Central Michigan
Iowa +3.5 Iowa vs Iowa State
Oregon -28 Oregon vs Oklahoma State
Kentucky +8.5 Kentucky vs Ole Miss
UNLV ML UNLV vs UCLA
Oklahoma -5 Oklahoma vs Michigan

6 Picks for College Football Week 2

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